CORDIS · 101078247 · HORIZON
PROTEGE Profile nucleases and Repurpose Off-Targets to Expand Gene Editing
Coordinator: VILNIAUS UNIVERSITETAS (LT)
Programmable nucleases reside at the nexus of advanced gene editing and microbial defense. These nucleases degrade phage DNA but avoid genomic DNA to provide the microbe with adaptive immunity. The standard-bearer, CRISPR-Cas9, relies on a guide RNA (gRNA) – its program – to precisely cut a complimentary genetic sequence – its target – for precision gene editing. These programmable nucleases deliver cure for genetic diseases like anemia, blindness, and cancer; quick disease model development; and diagnostics for viruses like SARS-CoV-2.Hunts across microbial genomes have exposed thousands of …
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €1.1M awarded to the consortium. The project runs over approximately 5 years from 2023-06-01 to 2028-05-31.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from LT
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Other HORIZON projects
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- PARC — Partnership for the Assessment of Risks from Chemicals101057014 · FR · €200.0M
- EIT RM BP23-25 — EIT RawMatrials Business Plan 2023-2025101113034 · DE · €155.5M
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC funding scheme.
- What is the EU contribution?
- The European Commission contributes €1.1M toward a total project budget of €1.1M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2022-STG.
- Who coordinates the project?
- The project is coordinated by VILNIAUS UNIVERSITETAS (LT).
- What is the project timeline?
- The project runs from 2023-06-01 to 2028-05-31 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101078247.