CORDIS · 101109424 · HORIZON
INCEPTOR Investigate the mode of action ofInvestigate the mode of action of beta-carboline derivative Harmine on increasing MHC-I expression and potentiating the Immune Checkpoint Blockade cancer immunotherapy
Coordinator: LUXEMBOURG INSTITUTE OF HEALTH (LU)
One of the major mechanisms by which solid tumors escape anti-tumor immunity is the downregulation of major histocompatibility complex class I (MHC-I), which causes a failure in the recognition of tumor cells by the cytotoxicity T-cells. The project proposed by Dr. Teresa Ramos contains basic and translational aspects. The basic aspect relies on investigating the mechanisms of action of the ACB1801 molecule (harmine), reported by the host team to restore the MHC-I in tumor cells, using state-of-the-art technologies. The translational aspect of the project relies on providing the preclinical p…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
0 EU contribution: €192k awarded to the consortium. The project runs over approximately 2 years from 2024-04-01 to 2026-03-31.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from LU
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-TMA-MSCA-PF-EF funding scheme.
- What is the EU contribution?
- The European Commission contributes €192k.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call HORIZON-MSCA-2022-PF-01.
- Who coordinates the project?
- The project is coordinated by LUXEMBOURG INSTITUTE OF HEALTH (LU).
- What is the project timeline?
- The project runs from 2024-04-01 to 2026-03-31 — approximately 2 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101109424.