CORDIS · 101124557 · HORIZON
4M8 Formate-dependent Regulation of Cancer Metastasis
Coordinator: LUXEMBOURG INSTITUTE OF HEALTH (LU)
Mechanisms underlying cancer metastasis are poorly understood and context dependent. An essential feature of disseminating cancer cells is metabolic plasticity which allows cellular adaptation to changing environmental conditions along the metastatic cascade. I discovered in 2016 the phenomenon of formate overflow, an alternative pathway for serine catabolism via folate-mediated one-carbon (1C) cycle. Instead of using formate for nucleotide synthesis (to support proliferation), formate overflow is characterised by formate excretion from cancer cells. Furthermore, I have convincingly demonstra…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €2.0M awarded to the consortium. The project runs over approximately 5 years from 2024-05-01 to 2029-04-30.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from LU
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC funding scheme.
- What is the EU contribution?
- The European Commission contributes €2.0M toward a total project budget of €2.0M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2023-COG.
- Who coordinates the project?
- The project is coordinated by LUXEMBOURG INSTITUTE OF HEALTH (LU).
- What is the project timeline?
- The project runs from 2024-05-01 to 2029-04-30 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101124557.