CORDIS · 101140394 · HORIZON
CADABRE Computational design of synthetic antibody repertoires for accelerated therapeutic discovery
Coordinator: WEIZMANN INSTITUTE OF SCIENCE (IL)
Synthetic human antibody repertoires are an important source of therapeutics; however, antibodies often exhibit undesirable developability liabilities, such as low stability, solubility, and polyreactivity, that limit their potential as drug candidates. CADABRE will design next-generation repertoires comprising billions of diverse human antibodies that exhibit excellent developability properties, with the following aims:1. Repertoire design: We will use our newly developed combinatorial Rosetta atomistic design paradigm to select human germline genes and design H3 multipoint mutants. These wi…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €2.7M awarded to the consortium. The project runs over approximately 5 years from 2024-08-01 to 2029-07-31.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from IL
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC funding scheme.
- What is the EU contribution?
- The European Commission contributes €2.7M toward a total project budget of €2.7M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2023-ADG.
- Who coordinates the project?
- The project is coordinated by WEIZMANN INSTITUTE OF SCIENCE (IL).
- What is the project timeline?
- The project runs from 2024-08-01 to 2029-07-31 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101140394.