CORDIS · 101141357 · HORIZON
MechanoResistance Overcoming Mechanically-Induced Resistance to Chemo-Immunotherapy in Pancreatic Cancer
Coordinator: UNIVERSITY OF CYPRUS (CY)
Cancer progression is closely associated with generation of mechanical stresses that cause the compression of tumor vessels, drastically reducing delivery of drugs. My co-workers and I found that host cells and extracellular matrix in tumors generate these stresses. Furthermore, we identified the anti-hypertensive losartan to alleviate intratumoral stresses and decompress vessels, allowing drugs to enter the tumor. My colleagues tested losartan in pancreatic cancer patients and found improved responses to chemo-radiation. Nonetheless, losartan cannot alleviate all stresses, and my preliminary…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €2.5M awarded to the consortium. The project runs over approximately 5 years from 2025-04-01 to 2030-03-31.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from CY
see all →- PHAETHON — PHAETHON Research and Innovation Centre of Excellence for Intelligent, Efficient and Sustainable Energy Solutions101059898 · HORIZON · €15.0M
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- KIOS CoE — KIOS Research and Innovation Centre of Excellence739551 · H2020 · €15.0M
- CY-BIOBANK — Biobanking and the Cyprus Human Genome Project857122 · H2020 · €15.0M
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- Water-Futures — Smart Water Futures: designing the next generation of urban drinking water systems951424 · H2020 · €10.0M
Other HORIZON projects
see all →- EUROfusion — Implementation of activities described in the Roadmap to Fusion during Horizon Europe through a joint programme of the members of the EUROfusion consortium101052200 · DE · €549.4M
- EITUM-BP26-28 — EIT Urban Mobility Business Plan 2026-2028101269525 · ES · €206.9M
- PARC — Partnership for the Assessment of Risks from Chemicals101057014 · FR · €200.0M
- EIT RM BP23-25 — EIT RawMatrials Business Plan 2023-2025101113034 · DE · €155.5M
- SGA1-HE — COST: Europe's most empowering research programme Strengthening science and innovation through research networking101052416 · BE · €153.0M
- EIT HEI — EIT Higher Education Initiative - Scaling Europe’s Innovation Ecosystems101270329 · DE · €130.0M
Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC funding scheme.
- What is the EU contribution?
- The European Commission contributes €2.5M toward a total project budget of €2.5M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2023-ADG.
- Who coordinates the project?
- The project is coordinated by UNIVERSITY OF CYPRUS (CY).
- What is the project timeline?
- The project runs from 2025-04-01 to 2030-03-31 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101141357.