CORDIS · 101142726 · HORIZON
Ubi-Wan The origin and impact of impaired ubiquitin signaling in the degeneration of neurons
Coordinator: TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY (IL)
Neurodegenerative diseases share similar hallmarks such as protein aggregation, suggesting that impaired protein degradation may be a common denominator. The major cellular pathways mediating protein degradation are the Ubiquitin-proteasome system (UPS) and autophagy, both regulated by ubiquitin signaling. However, aside from specific mutations in familial neurodegeneration cases, an early cause for failing ubiquitin-dependent proteolysis remains unclear. This proposal will test our unconventional hypothesis that dysregulated ubiquitin signaling is an early event in mechanisms of neurodegener…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €2.5M awarded to the consortium. The project runs over approximately 5 years from 2024-11-01 to 2029-10-31.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from IL
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Other HORIZON projects
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC funding scheme.
- What is the EU contribution?
- The European Commission contributes €2.5M toward a total project budget of €2.5M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2023-ADG.
- Who coordinates the project?
- The project is coordinated by TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY (IL).
- What is the project timeline?
- The project runs from 2024-11-01 to 2029-10-31 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101142726.