CORDIS · 101162783 · HORIZON
EditYR Expanding the genome editing toolbox by rational reprogramming of tyrosine recombinase DNA specificities
Coordinator: KEMIJSKI INSTITUT (SI)
Gene therapies aim to cure genetic diseases by modifying the DNA blueprint. An ideal gene therapy should be durable, safe, and efficient, which often requires integration of large therapeutic DNA cargo at precise genomic locations. Advanced DNA editors with programmable specificities, such as the CRISPR technology, are limited by the nuclease-based mechanism and poor efficiency of large DNA insertions. Increased efficiency, specificity and precision of large edits are required to address a broad therapeutic space.Tyrosine recombinases (YRs) efficiently rearrange large DNA segments without the…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €1.6M awarded to the consortium. The project runs over approximately 5 years from 2025-04-01 to 2030-03-31.
Full record on CORDIS — partners, deliverables, publications, news.
Open on cordis.europa.eu → Grant DOI ↗More from SI
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC funding scheme.
- What is the EU contribution?
- The European Commission contributes €1.6M toward a total project budget of €1.6M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2024-STG.
- Who coordinates the project?
- The project is coordinated by KEMIJSKI INSTITUT (SI).
- What is the project timeline?
- The project runs from 2025-04-01 to 2030-03-31 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101162783.