CORDIS · 101224824 · HORIZON

GeneMotors Genome control by DNA-looping motors: from folding to function

Coordinator: TECHNISCHE UNIVERSITEIT DELFT (NL)

Our genome is not merely an information code but also a physical object: a long polymer of DNA with a dynamic three-dimensional organisation that is crucial for its function. Recently, we and others discovered that SMC protein complexes are a novel class of remarkable molecular motors that extrude loops of DNA. While insights into how this motor activity shapes chromosomes are revolutionising our understanding of chromosome structure, it is becoming clear that SMC motors are also key to controlling the expression of genetic information – a core function of cells.GeneMotors seeks to tackle the…

EU contribution
€10.0M
Total cost
€10.0M
Period
2026-02-01 → 2032-01-31
Framework
Horizon Europe (2021–2027)
Funding scheme
HORIZON-ERC-SYG
Call
ERC-2025-SyG
Status
SIGNED

About Horizon Europe (2021–2027)

Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.

EU contribution: €10.0M awarded to the consortium. The project runs over approximately 6 years from 2026-02-01 to 2032-01-31.

Full record on CORDIS — partners, deliverables, publications, news.

Open on cordis.europa.eu → Grant DOI ↗

Frequently asked questions

Who funds this research project?
This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC-SYG funding scheme.
What is the EU contribution?
The European Commission contributes €10.0M toward a total project budget of €10.0M.
Which EU programme funds it?
The project is funded under Horizon Europe (2021–2027), call ERC-2025-SyG.
Who coordinates the project?
The project is coordinated by TECHNISCHE UNIVERSITEIT DELFT (NL).
What is the project timeline?
The project runs from 2026-02-01 to 2032-01-31 — approximately 6 years.
Where can I find the full project record?
The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101224824.