CORDIS · 101167180 · HORIZON
MUTAHOME Mutations in healthy tissues: a double-edged sword for tissues homeostasis
Coordinator: THE FRANCIS CRICK INSTITUTE LIMITED (UK)
Healthy tissues become progressively populated of clonally expanded cells that have acquired somatic mutations. Often these mutations modify cancer genes promoting cell plasticity, self-renewal, and growth, all features known to decline with ageing. Despite being pervasive across tissues and persistent throughout life, only rarely mutant cells become pathogenic. Here we hypothesise that somatic mutations enhance tissue integrity by increasing the fitness of stem/progenitor cells (SPCs) to counterbalance their age-induced decline. Increased SPC fitness at the cellular level increases the fitne…
About Horizon Europe (2021–2027)
Horizon Europe is the EU's current research and innovation programme, covering 2021 to 2027 with a budget of roughly €95.5 billion. Its three pillars are Excellent Science (frontier research and mobility), Global Challenges and European Industrial Competitiveness (mission-driven collaborative projects in health, climate, digital, security and food) and Innovative Europe (the EIC and EIT). It also funds five EU Missions targeting cancer, climate adaptation, smart cities, oceans and soils.
EU contribution: €9.8M awarded to the consortium. The project runs over approximately 6 years from 2025-09-01 to 2031-08-31.
Full record on CORDIS — partners, deliverables, publications, news.
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon Europe (2021–2027) programme, under the HORIZON-ERC-SYG funding scheme.
- What is the EU contribution?
- The European Commission contributes €9.8M toward a total project budget of €9.8M.
- Which EU programme funds it?
- The project is funded under Horizon Europe (2021–2027), call ERC-2024-SyG.
- Who coordinates the project?
- The project is coordinated by THE FRANCIS CRICK INSTITUTE LIMITED (UK).
- What is the project timeline?
- The project runs from 2025-09-01 to 2031-08-31 — approximately 6 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 101167180.