CORDIS · 647403 · H2020
D-FENS Dicer-Dependent Defense in Mammals
Coordinator: USTAV MOLEKULARNI GENETIKY AV CR V.V.I. (CZ)
Viral infection or retrotransposon expansion in the genome often result in production of double-stranded RNA (dsRNA). dsRNA can be intercepted by RNase III Dicer acting in the RNA interference (RNAi) pathway, an ancient eukaryotic defense mechanism. Notably, endogenous mammalian RNAi appears dormant while its common and unique physiological roles remain poorly understood. A factor underlying mammalian RNAi dormancy is inefficient processing of dsRNA by the full-length Dicer. Yet, a simple truncation of Dicer leads to hyperactive RNAi, which is naturally present in mouse oocytes.The D-FENS pro…
About Horizon 2020 (2014–2020)
Horizon 2020 was the EU's flagship research and innovation programme for 2014–2020, with a budget of around €77 billion. It bundled FP7's strands with the EIT and the Competitiveness and Innovation Programme, introduced a stronger societal-challenge orientation, and pushed the funding logic toward closer-to-market innovation. New calls closed in 2020 but funded projects continued through 2024.
EU contribution: €1.9M awarded to the consortium. The project runs over approximately 5 years from 2015-07-01 to 2020-06-30.
Full record on CORDIS — partners, deliverables, publications, news.
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Frequently asked questions
- Who funds this research project?
- This project is funded by the European Union through the Horizon 2020 (2014–2020) programme, under the ERC-COG funding scheme.
- What is the EU contribution?
- The European Commission contributes €1.9M toward a total project budget of €1.9M.
- Which EU programme funds it?
- The project is funded under Horizon 2020 (2014–2020), call ERC-2014-CoG.
- Who coordinates the project?
- The project is coordinated by USTAV MOLEKULARNI GENETIKY AV CR V.V.I. (CZ).
- What is the project timeline?
- The project runs from 2015-07-01 to 2020-06-30 — approximately 5 years.
- Where can I find the full project record?
- The complete record — partners, deliverables, publications and news — is published on CORDIS under project ID 647403.